RESEARCH

Cytokinesis is the physical separation of a cell into two daughter cells. This process is highly conserved across metazoans and is driven by an actomyosin contractile ring. Tight spatiotemporal regulation of cytokinesis ensures that the division plane is maintained between the
segregating sister chromatids, thereby preventing aneuploidy or changes in cell fate. Studies in our lab recently showed how a chromatin-derived cue, Ran-GTP, regulates cytokinesis in mammalian cells by controlling how importins bind to anillin’s nuclear localization signal (NLS) for its cortical recruitment and function.